The crash occurred shortly after 4 p.m. Sunday on Route 68 in Connoquenessing.
Authorities say 53-year-old Anthony McCoppin, of Blawnox, was driving eastbound when he hit the deer. The animal went airborne, directly into the path of the westbound SUV driven by 73-year-old Michael Modjallal, 73, of Akron, Ohio.
The deer hit the upper windshield of Modjallal's SUV and went into the vehicle, causing fatal injuries to Modjallal. A passenger in his SUV, 70-year-old Lucia Modjallal of Akron, was hospitalized with undisclosed injuries.
McCoppin wasn't hurt.
The crash remains under investigation.